Article
Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era.
BMC medical genomics - 22 May 2014
Swindell William R, Stuart Philip E, Sarkar Mrinal K, Voorhees John J, Elder James T, Johnston Andrew, Gudjonsson Johann E
Abstract excerpt
BACKGROUND: Genome-scale studies of psoriasis have been used to identify genes of potential relevance to disease mechanisms. For many identified genes, however, the cell type mediating disease activity is uncertain, which has limited our ability to design gene functional studies based on genomic findings. METHODS: We identified differentially expressed genes (DEGs) with altered expression in psoriasis lesions...
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