Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian randomization reveals DNA methylation-related pyroptosis genes associated with psoriasis risk.

Clinical epigenetics - 12 Mar 2026

Dong Wenwu, Shi Cuiping

Abstract excerpt

BACKGROUND: Research has indicated a connection between pyroptosis and psoriasis, yet the specific genes involved remain largely unidentified. This study employed Mendelian randomization (MR) to evaluate the potential causal impact of both pyroptosis-related genes and DNA methylation signatures on psoriasis risk. METHODS: Pyroptosis-related genes were sourced from the GeneCards database. We integrated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to ADAR gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Psoriasis

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41821112
DOI: 10.1186/s13148-026-02063-7
PMCID: PMC12980989

Genes

ADAR
DNMT3B
KIF11
NFKB1
PROM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian randomization reveals DNA methylation-related pyroptosis genes associated with psoriasis risk.PMID 41821112Read ↗

Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasisSemantic proximity Read ↗

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for PsoriasisSemantic proximity Read ↗

Proteome-wide Mendelian randomization and colocalization analysis identify potential drug targets for psoriasisSemantic proximity Read ↗

Identifying novel risk targets in inflammatory skin diseases by comprehensive proteome-wide Mendelian randomization studySemantic proximity Read ↗

Mapping the Causal Landscape of Psoriasis: A Systematic Mendelian Randomization Evidence Synthesis and Development of the MR-PsO Atlas Platform.Semantic proximity Read ↗

Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis.Semantic proximity Read ↗

Identification of Potential Biomarkers for Psoriasis by DNA Methylation and Gene Expression DatasetsSemantic proximity Read ↗

Role of miRNAs in the pathogenesis of psoriasis and psoriatic arthritis: a genome-wide Mendelian randomization studySemantic proximity Read ↗

Genetic, Epigenetic and Pharmacogenetic Aspects of Psoriasis and Psoriatic Arthritis.Semantic proximity Read ↗

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targetsSemantic proximity Read ↗

Phenome-wide Mendelian randomization analysis reveals new risk factors for 4 inflammatory skin diseases.Semantic proximity Read ↗

An observational and genetic investigation into the association between psoriasis and risk of malignancy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.