Article
Male development of chromosomally female mice transgenic for Sry.
Nature - 9 May 1991
Koopman P, Gubbay J, Vivian N, Goodfellow P, Lovell-Badge R
Abstract excerpt
The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kiloba...
Topics
- Animals
- DNA
- Female
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Transgenic
- Morphogenesis
- Phenotype
- Regulatory Sequences, Nucleic Acid
- Restriction Mapping
- Sex Determination Analysis
- Species Specificity
- Testis
- X Chromosome
- Y Chromosome