Article
Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more.
Biology of sex differences - 21 Feb 2026
Arnold Arthur P, Chen Xuqi, Grzybowski Michael N, Ryan Janelle M, Sengelaub Dale R, Mohanroy Tara, Furlan V Andree, Schmidtke Helen R, Prokop Jeremy W, Tutaj Monika, Ciosek Julia L, Kalbfleisch Theodore S, O'Donnell Liza, Grisham William, Landen Shanie, Malloy Lynn, Takizawa Akiko, Li Kai, Barseghyan Hayk, Wiese Carrie B, Vergnes Laurent, Reue Karen, Wanagat Jonathan, Skaletsky Helen, Page David C, Harley Vincent R, Dwinell Melinda R, Geurts Aron M
Abstract excerpt
BACKGROUND: Previous research on Four Core Genotypes and XY* mice has been instrumental in establishing important effects of sex-chromosome complement that cause sex differences in physiology and disease. We have generated rat models using similar modifications of the testis-determining gene Sry, to produce XX and XY rats with the same type of gonad, as well as XO, XXY and XYY rats with varying gonads. The models...
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