Article

<i>Sry</i> -modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more

2023-02-10

Abstract excerpt

<h4>Background</h4> Previous research on Four Core Genotypes and XY* mice has been instrumental in establishing important effects of sex-chromosome complement that cause sex differences in physiology and disease. We have generated rat models using similar modifications of the testis-determining gene Sry , to produce XX and XY rats with the same type of gonad, as well as XO, XXY and XYY rats with varying gonads....

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Literature Corpus work: b8bf977b-9aeb-5816-9a20-e03a18c06009
DOI: 10.1101/2023.02.09.527738

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