Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice.

Biological psychiatry - 15 Sept 2015

Foote Molly, Qiao Haifa, Graham Kourtney, Wu Yuying, Zhou Yi

Abstract excerpt

BACKGROUND: The 14-3-3 family of proteins is implicated in the regulation of several key neuronal processes. Previous human and animal studies suggested an association between 14-3-3 dysregulation and schizophrenia. METHODS: We characterized behavioral and functional changes in transgenic mice that express an isoform-independent 14-3-3 inhibitor peptide in the brain. RESULTS: We recently showed that 14-3-3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Catenins
Share to Clozapine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Delta Catenin

Share to Dendrites

Share to Haloperidol

Share to Receptors, Dopamine

Share to Schizophrenic Psychology

Source

Open in PubMed Open full text

Identifiers

PMID: 25863357
DOI: 10.1016/j.biopsych.2015.02.015
PMCID: PMC4544659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice.PMID 25863357Read ↗

Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.Semantic proximity Read ↗

Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities.Semantic proximity Read ↗

Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors.Semantic proximity Read ↗

SHANK3 Mutations Associated with Autism and Schizophrenia Lead to Shared and Distinct Changes in Dendritic Spine Dynamics in the Developing Mouse Brain.Semantic proximity Read ↗

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.Semantic proximity Read ↗

Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes.Semantic proximity Read ↗

Neuroligin‐3‐deficient mice: model of a monogenic heritable form of autism with an olfactory deficitSemantic proximity Read ↗

Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder.Semantic proximity Read ↗

The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.Semantic proximity Read ↗

Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene.Semantic proximity Read ↗

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia.Semantic proximity Read ↗

Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.