Article
Genetic and post-mortem mRNA analysis of the 14-3-3 genes that encode phosphoserine/threonine-binding regulatory proteins in schizophrenia and bipolar disorder.
Schizophrenia research - 15 Oct 2005
Wong Albert H C, Likhodi Olga, Trakalo Joseph, Yusuf Muneeb, Sinha Anuradha, Pato Carlos N, Pato Michele T, Van Tol Hubert H M, Kennedy James L
Abstract excerpt
BACKGROUND: Previous work with animal models of psychosis, human genetic studies, and human post-mortem gene expression studies implicate the 14-3-3 family of genes in schizophrenia. The 14-3-3 genes code for a family of proteins that bind to and regulate other proteins, and they modulate neurodevelopment, cell-division, signal transduction and gene transcription. OBJECTIVE: To explore the role of five 14-3-3...
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