Article
Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene.
Molecular psychiatry - 1 Feb 2003
Wong A H C, Macciardi F, Klempan T, Kawczynski W, Barr C L, Lakatoo S, Wong M, Buckle C, Trakalo J, Boffa E, Oak J, Azevedo M-H, Dourado A, Coelho I, Macedo A, Vicente A, Valente J, Ferreira C P, Pato M T, Pato C N, Kennedy J L, Van Tol H H M
Abstract excerpt
Although the genetic contribution to schizophrenia is substantial, positive findings in whole-genome linkage scans have not been consistently replicated. We analyzed gene expression in various rat conditions to identify novel candidate genes for schizophrenia. Suppression subtraction hybridization (SSH), with polyA mRNA from temporal and frontal cortex of rats, was used to identify differentially expressed genes....
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