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Article

Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors.

Neuron - 7 Sept 2016

Martinelli David C, Chew Kylie S, Rohlmann Astrid, Lum Matthew Y, Ressl Susanne, Hattar Samer, Brunger Axel T, Missler Markus, Südhof Thomas C

Abstract excerpt

C1ql3 is a secreted neuronal protein that binds to BAI3, an adhesion-class GPCR. C1ql3 is homologous to other gC1q-domain proteins that control synapse numbers, but a role for C1ql3 in regulating synapse density has not been demonstrated. We show in cultured neurons that C1ql3 expression is activity dependent and supports excitatory synapse density. Using newly generated conditional and constitutive C1ql3...

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Identifiers

PMID: 27478018
DOI: 10.1016/j.neuron.2016.07.002
PMCID: PMC5017910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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