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Article

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.

The EMBO journal - 2 Jan 2020

Alsabban Ashwaq Hassan, Morikawa Momo, Tanaka Yosuke, Takei Yosuke, Hirokawa Nobutaka

Abstract excerpt

The transport of N-methyl-d-aspartate receptors (NMDARs) is crucial for neuronal plasticity and synapse formation. Here, we show that KIF3B, a member of the kinesin superfamily proteins (KIFs), supports the transport of vesicles simultaneously containing NMDAR subunit 2A (NR2A) and the adenomatous polyposis coli (APC) complex. Kif3b+/- neurons exhibited a reduction in dendritic levels of both NR2A and NR2B due to...

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Identifiers

PMID: 31746486
DOI: 10.15252/embj.2018101090
PMCID: PMC6939202

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