Article
Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.
Molecular psychiatry - 1 Apr 2012
Cheah P S, Ramshaw H S, Thomas P Q, Toyo-Oka K, Xu X, Martin S, Coyle P, Guthridge M A, Stomski F, van den Buuse M, Wynshaw-Boris A, Lopez A F, Schwarz Q P
Abstract excerpt
Complex neuropsychiatric disorders are believed to arise from multiple synergistic deficiencies within connected biological networks controlling neuronal migration, axonal pathfinding and synapse formation. Here, we show that deletion of 14-3-3ζ causes neurodevelopmental anomalies similar to those seen in neuropsychiatric disorders such as schizophrenia, autism spectrum disorder and bipolar disorder....
Topics
- 14-3-3 Proteins
- Animals
- Brain
- Cell Movement
- Cells, Cultured
- Disease Models, Animal
- Female
- Genetic Predisposition to Disease
- Hippocampus
- Male
- Maze Learning