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Article

Comprehensive behavioral phenotyping of male Septin 3-deficient mice reveals task-specific abnormalities.

Molecular brain - 22 Aug 2025

Ageta-Ishihara Natsumi, Takao Keizo, Miyakawa Tsuyoshi, Kinoshita Makoto

Abstract excerpt

The septin cytoskeleton is recognized as the fourth component of the cytoskeleton. Septin 3 (SEPT3)/G-septin is a neuron-selective subunit of the septin family and is widely expressed in mature neurons. We previously demonstrated that SEPT3 regulates long-term potentiation (L-LTP)-dependent extension of smooth endoplasmic reticulum (sER) into dendritic spines of granule cells in the hippocampal dentate gyrus...

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Identifiers

PMID: 40846958
DOI: 10.1186/s13041-025-01243-5
PMCID: PMC12374300

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