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Article

Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics.

Biological psychiatry - 15 Jul 2015

Zimmermann Anika-Maria, Jene Tanja, Wolf Michael, Görlich Andreas, Gurniak Christine B, Sassoè-Pognetto Marco, Witke Walter, Friauf Eckhard, Rust Marco B

Abstract excerpt

BACKGROUND: Actin depolymerizing proteins of the actin depolymerizing factor (ADF)/cofilin family are essential for actin dynamics, which is critical for synaptic function. Two ADF/cofilin family members, ADF and n-cofilin, are highly abundant in the brain, where they are present in excitatory synapses. Previous studies demonstrated the relevance of n-cofilin for postsynaptic plasticity, associative learning, and...

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PMID: 24768258
DOI: 10.1016/j.biopsych.2014.03.011

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