Article
Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
Circulation - 9 Jun 2015
Desikan Rahul S, Schork Andrew J, Wang Yunpeng, Thompson Wesley K, Dehghan Abbas, Ridker Paul M, Chasman Daniel I, McEvoy Linda K, Holland Dominic, Chen Chi-Hua, Karow David S, Brewer James B, Hess Christopher P, Williams Julie, Sims Rebecca, O'Donovan Michael C, Choi Seung Hoan, Bis Joshua C, Ikram M Arfan, Gudnason Vilmundur, DeStefano Anita L, van der Lee Sven J, Psaty Bruce M, van Duijn Cornelia M, Launer Lenore, Seshadri Sudha, Pericak-Vance Margaret A, Mayeux Richard, Haines Jonathan L, Farrer Lindsay A, Hardy John, Ulstein Ingun Dina, Aarsland Dag, Fladby Tormod, White Linda R, Sando Sigrid B, Rongve Arvid, Witoelar Aree, Djurovic Srdjan, Hyman Bradley T, Snaedal Jon, Steinberg Stacy, Stefansson Hreinn, Stefansson Kari, Schellenberg Gerard D, Andreassen Ole A, Dale Anders M
Abstract excerpt
BACKGROUND: Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this phenotypic association arises from a shared genetic basis. METHODS AND RESULTS: Using summary statistics (P values and odds ratios) from genome-wide association studies of >200 000 individuals, we...
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