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Article

A phenome-wide hunt for risk factors of Alzheimer's disease: from metabolic clues to neuroimaging evidence.

Journal of translational medicine - 5 Feb 2026

Liu Dongming, Baranova Ancha, Sun Wenxi, Cao Hongbao, Zhang Bing, Zhang Fuquan

Abstract excerpt

BACKGROUND: This study systematically investigated phenotypes causally associated with Alzheimer's disease (AD) across the phenome and validated the findings at cognitive and neuroimaging levels using real-world clinical data. METHODS: We performed phenome-wide Mendelian Randomization (MR) analyses on genetic proxies for over 860 disease phenotypes to identify traits causally associated with AD. Lipid...

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Identifiers

PMID: 41645184
DOI: 10.1186/s12967-026-07756-4
PMCID: PMC12973621

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CA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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