Article
Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice.
Clinical immunology (Orlando, Fla.) - 1 Jun 2015
Yoachim Shayla D, Nuxoll Jenny S, Bynoté Kimberly K, Gould Karen A
Abstract excerpt
Sex bias in lupus incidence is thought to be due, in part, to the ability of estrogens to promote loss of tolerance. Previously, we showed that estrogens promote lupus via estrogen receptor α (ERα). C57BL/6 (B6) mice carrying the Sle1 lupus susceptibility locus (B6.Sle1) display loss of tolerance and develop anti-nuclear antibodies and immune cell hyperactivation. The incidence of loss of tolerance in B6.Sle1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.