Article
The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2002
Sobel Eric S, Satoh Minoru, Chen Yifang, Wakeland Edward K, Morel Laurence
Abstract excerpt
Sle1 is a major susceptibility locus in the NZM2410 murine model of systemic lupus erythematosus. When isolated on a C57BL/6 background in the B6.Sle1 congenic strain, Sle1 results in the production of high levels of anti-chromatin IgG Abs, histone-specific T cells, and increased B and T cell activation. We have shown by mixed bone marrow chimeras with allotypic markers that Sle1 is expressed in B cells. Using...
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