Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus.

Genes and immunity - 1 Dec 2003

Croker B P, Gilkeson G, Morel L

Abstract excerpt

Interactions between Sle1 and other susceptibility loci were required for disease development in the NZM2410 model of lupus. Sle1 corresponds to at least three subloci, Sle1a, Sle1b, and Sle1c, each of which independently causes loss of tolerance to chromatin, but displays a distinctive immune profile. We have used congenic strains to analyze the interactions between the Sle1 subloci and other lupus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmunity
Share to Enzyme-Linked Immunosorbent Assay
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulocytes

Share to Immunoglobulin G

Share to Lupus Erythematosus, Systemic

Share to Lymphocytes

Share to Spleen

Source

Identifiers

PMID: 14647198
DOI: 10.1038/sj.gene.6364028

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus.PMID 14647198Read ↗

Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.Semantic proximity Read ↗

Genetic Dissection of SLESemantic proximity Read ↗

Susceptibility genes in the pathogenesis of murine lupus.Semantic proximity Read ↗

The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice.Semantic proximity Read ↗

Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci.Semantic proximity Read ↗

The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes.Semantic proximity Read ↗

Genetics of systemic autoimmunity in mouse models of lupus.Semantic proximity Read ↗

The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells.Semantic proximity Read ↗

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodiesSemantic proximity Read ↗

Functional dissection of systemic lupus erythematosus using congenic mouse strains.Semantic proximity Read ↗

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strainsSemantic proximity Read ↗

<i> FAS <sup>lpr</sup> </i> gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.