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Article

Genetic determination of T cell help in loss of tolerance to nuclear antigens.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2005

Chen Yifang, Cuda Carla, Morel Laurence

Abstract excerpt

Sle1 is a major lupus susceptibility locus in NZM2410 lupus model that is associated with a loss of tolerance to nuclear Ags. At least three genes, Sle1a, Sle1b, and Sle1c contribute to Sle1, and their relative role in lupus pathogenesis is unknown. We show here that Sle1-expressing CD4(+) T cells present an activated phenotype associated with increased proliferation and cytokine production. In addition, Sle1...

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Share to Antibodies, Antinuclear
Share to Antigens, Nuclear
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immune Tolerance

Share to Immunoglobulin G

Share to Lupus Erythematosus, Systemic

Share to T-Lymphocytes, Helper-Inducer

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 15944270
DOI: 10.4049/jimmunol.174.12.7692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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