Article
Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2012
Cuda Carla M, Li Shiwu, Liang Shujuan, Yin Yiming, Potula Hari Hara S K, Xu Zhiwei, Sengupta Mayami, Chen Yifang, Butfiloski Edward, Baker Henry, Chang Lung-Ji, Dozmorov Igor, Sobel Eric S, Morel Laurence
Abstract excerpt
Sle1a.1 is part of the Sle1 susceptibility locus, which has the strongest association with lupus nephritis in the NZM2410 mouse model. In this study, we show that Sle1a.1 results in the production of activated and autoreactive CD4(+) T cells. Additionally, Sle1a.1 expression reduces the peripheral regulatory T cell pool, as well as induces a defective response of CD4(+) T cells to the retinoic acid expansion of...
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