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Article

The induction of the lupus phenotype by estrogen is via an estrogen receptor-alpha-dependent pathway.

Clinical immunology (Orlando, Fla.) - 1 Feb 2010

Feng Feng, Nyland Jennifer, Banyai Michelle, Tatum Arthur, Silverstone Allen E, Gavalchin Jerrie

Abstract excerpt

In order to investigate the roles of ER subtypes in the estrogen-induced lupus phenotype, ERalpha-deficient (ERalpha(-/-)) and wild-type mice (WT) were injected monthly with estradiol (E-2) starting at 8 weeks. In WT mice, E-2 treatment induced a lupus phenotype, with accelerated death and increased kidney damage, as well as Th2-type serum cytokine and autoantibody production. In contrast, only minimal changes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19926524
DOI: 10.1016/j.clim.2009.10.004

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