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Article

The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes.

Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2001

Morel L, Blenman K R, Croker B P, Wakeland E K

Abstract excerpt

The major murine systemic lupus erythematosus (SLE) susceptibility locus Sle1 is syntenic to a chromosomal region linked with SLE susceptibility in multiple human studies. Congenic analyses have shown that Sle1 breaks tolerance to chromatin, a necessary step for full disease induction that can be suppressed by specific modifier loci. In the present study, our fine mapping analysis of the location of Sle1 has...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11172029
DOI: 10.1073/pnas.98.4.1787
PMCID: PMC29335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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