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HIV-1 3΄ polypurine tract mutations and integrase inhibitor resistance.

AIDS (London, England) - 15 Nov 2025

Bishop Marley D, Xu Lixin, Boyce Ceejay L, Drain Paul K, Farquhar Carey, Hawes Stephen E, Frenkel Lisa M, Gottlieb Geoffrey S, Smith Robert A

Abstract excerpt

The WHO recommends the use of the integrase strand transfer inhibitor (INSTI) dolutegravir for first-line antiretroviral therapy (ART) in all adults living with HIV infection. Although dolutegravir-based ART is well tolerated and effective, mutations in the integrase-encoding region of HIV-1 pol that confer resistance to dolutegravir can undermine treatment efficacy. An alternative pathway to dolutegravir...

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PMID: 41603872
DOI: 10.1097/QAD.0000000000004315

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