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Article

Effects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavage.

Journal of virology - 1 Dec 2004

Julias John G, McWilliams Mary Jane, Sarafianos Stefan G, Alvord W Gregory, Arnold Eddy, Hughes Stephen H

Abstract excerpt

The RNase H cleavages that generate and remove the polypurine tract (PPT) primer during retroviral reverse transcription must be specific in order to create a linear viral DNA that is suitable for integration. Lentiviruses contain a highly conserved sequence consisting of six guanine residues at the 3' end of the PPT (hereafter referred to as the G tract). We introduced mutations into the G tract of a human...

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Identifiers

PMID: 15542682
DOI: 10.1128/JVI.78.23.13315-13324.2004
PMCID: PMC524982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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