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Article

Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches.

Journal of virology - 1 Jan 2005

Gitlin Leonid, Stone Jeffrey K, Andino Raul

Abstract excerpt

Short interfering RNAs (siRNAs) directed against poliovirus and other viruses effectively inhibit viral replication. Although RNA interference (RNAi) may provide the basis for specific antiviral therapies, the limitations of RNAi antiviral strategies are ill defined. Here, we show that poliovirus readily escapes highly effective siRNAs through unique point mutations within the targeted regions. Competitive...

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Identifiers

PMID: 15613331
DOI: 10.1128/JVI.79.2.1027-1035.2005
PMCID: PMC538575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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