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Article

Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration.

Journal of virology - 27 Jul 2022

Richetta Clémence, Subra Frédéric, Malet Isabelle, Leh Hervé, Charpentier Charlotte, Corona Angela, Collin Gilles, Descamps Diane, Deprez Eric, Parissi Vincent, Calvez Vincent, Tramontano Enzo, Marcelin Anne-Geneviève, Delelis Olivier

Abstract excerpt

Integration of the reverse-transcribed genome is a critical step of the retroviral life cycle. Strand-transfer inhibitors (INSTIs) used for antiretroviral therapy inhibit integration but can lead to resistance mutations in the integrase gene, the enzyme involved in this reaction. A significant proportion of INSTI treatment failures, particularly those with second-generation INSTIs, show no mutation in the...

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Identifiers

PMID: 35758669
DOI: 10.1128/jvi.00676-22
PMCID: PMC9327692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration.PMID 35758669Read ↗

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