Article
A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2003
Shaw Michael H, Boyartchuk Victor, Wong Sandy, Karaghiosoff Marina, Ragimbeau Josiane, Pellegrini Sandra, Muller Mathias, Dietrich William F, Yap George S
Abstract excerpt
The B10.Q/J strain of mice was serendipitously discovered to be highly susceptible to infection by the intracellular protozoan parasite, Toxoplasma gondii but markedly resistant to induction of autoimmune arthritis. We have previously shown that the B10.Q/J phenotype is controlled by a single recessive locus and is associated with lymphocyte hyporesponsiveness to IL-12. Using genetic approaches, we have now...
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