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Article

Type 2 Diabetes Reduces IFN-α2 and Compromises Antiviral Defense: Evidence From Mendelian Randomization and H1N1-Infected Diabetic Mice.

Diabetes - 1 Aug 2026

Lyu Siye, Wu Jiali, Ma Weihui, Sun Liping, Xing Sihui, Zhang Haiyang, Shao Fengyan, Li Mingquan, Zhu Yilong, Xiong Xiaomiao, Han Jicheng

Abstract excerpt

Type 2 diabetes (T2D) impairs antiviral immunity; however, the causal link between T2D and interferon-α2 (IFN-α2) deficiency remains unclear. This study used genome-wide association study-based Mendelian randomization (MR) to investigate this relationship and validated the findings in an H1N1-infected diabetic mouse model. MR analysis of 26 single nucleotide polymorphisms showed a significant negative association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 42283639
DOI: 10.2337/db25-0974
PMCID: PMC13381667

Genes

STAT3
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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