Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of Pregnane X Receptor Genetic Polymorphisms on Stable Warfarin Doses.

Journal of cardiovascular pharmacology and therapeutics - 1 Nov 2015

Moon Jung Yeon, Chang Byung Chul, Lee Kyung Eun, Bang Jun Seok, Gwak Hye Sun

Abstract excerpt

OBJECTIVE: Pregnane X receptor (PXR) is a transcriptional regulator of many drug-metabolizing enzymes including cytochrome P450 (CYP) 2C9. The objective of this study was to assess the possible association between PXR single-nucleotide polymorphisms (SNPs) and stable warfarin doses. METHODS: A total of 201 patients with stable warfarin doses from the EwhA-Severance Treatment (EAST) Group of Warfarin were included...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Cytochrome P-450 CYP2C9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Follow-Up Studies

Share to Heart Valve Prosthesis Implantation

Share to Heterozygote

Share to Pregnane X Receptor

Share to Receptors, Steroid

Share to Warfarin

Source

Identifiers

PMID: 25848132
DOI: 10.1177/1074248415578906

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of Pregnane X Receptor Genetic Polymorphisms on Stable Warfarin Doses.PMID 25848132Read ↗

Combined effects of hepatocyte nuclear factor 4α and constitutive androstane receptor on stable warfarin doses.Semantic proximity Read ↗

Polymorphisms of vitamin K-related genes (EPHX1 and VKORC1L1) and stable warfarin doses.Semantic proximity Read ↗

Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients.Semantic proximity Read ↗

Influence of genetic polymorphisms in cytochrome P450 oxidoreductase on the variability in stable warfarin maintenance dose in Han Chinese.Semantic proximity Read ↗

[Impact of five genetic polymorphisms on inter-individual variation in warfarin maintenance dose].Semantic proximity Read ↗

An evaluation of nine genetic variants related to metabolism and mechanism of action of warfarin as applied to stable dose prediction.Semantic proximity Read ↗

Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians.Semantic proximity Read ↗

Effects of EPHX1 rs2260863 polymorphisms on warfarin maintenance dose in very elderly, frail Han-Chinese population.Semantic proximity Read ↗

Effects of rare CYP2C9 alleles on stable warfarin doses in Chinese Han patients with atrial fibrillation.Semantic proximity Read ↗

Pregnane X receptor polymorphisms associated with human diseases.Semantic proximity Read ↗

Association of genetic polymorphisms with warfarin dose requirements in Chinese patients.Semantic proximity Read ↗

The impact of non-genetic and genetic factors on a stable warfarin dose in Thai patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.