Article
[Impact of five genetic polymorphisms on inter-individual variation in warfarin maintenance dose].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2011
Huang Sheng-wen, Xiang Dao-kang, Wu Hai-li, Chen Bao-lin, An Bang-quan, Li Gui-fang
Abstract excerpt
OBJECTIVE: To investigate the effect of genetic polymorphisms in VKORC1, CYP2C9, GGCX, EPHX1, APOE genes on inter-individual variation in warfarin maintenance dose. METHODS: Two hundred and forty-nine patients with stable warfarin dose were enrolled in this study, and the clinical data and blood samples of the patients were collected. Genotypes for the 5 genes were determined by using PCR and denaturing high...
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