Article
Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians.
BMC medical genetics - 6 Jun 2011
Suriapranata Ivet M, Tjong Wen Ye, Wang Tingliang, Utama Andi, Raharjo Sunu B, Yuniadi Yoga, Tai Susan Sw
Abstract excerpt
BACKGROUND: CYP2C9 and VKORC1 are two major genetic factors associated with inter-individual variability in warfarin dose. Additionally, genes in the warfarin metabolism pathway have also been associated with dose variance. We analyzed Single Nucleotide Polymorphisms (SNPs) in these genes to identify genetic factors that might confer warfarin sensitivity in Indonesian patients. METHODS: Direct sequencing method...
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