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Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy

6 Apr 2015

Abstract excerpt

The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily, which controls programs regulating cell proliferation, differentiation, and apoptosis. We have identified an unexpected role for GR in mitosis. We discovered that specifically modified GR species accumulate at the mitotic spindle during mitosis in a distribution that overlaps with Aurora kinases. We found that Aurora A was required...

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PMID: 25847991
DOI: 10.1073/pnas.1411356112

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