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Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor

26 Jun 2008

Abstract excerpt

Glucocorticoid (GC) receptors (GRs) have profound anti-survival effects on human small cell lung cancer (SCLC). To explore the basis of these effects, protein partners for GRs were sought using a yeast two-hybrid screen. We discovered a novel gene, FAM33A, subsequently identified as a SKA1 partner and involved in mitosis, and so renamed Ska2. We produced an anti-peptide antibody that specifically recognized...

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PMID: 18583474
DOI: 10.1677/joe-08-0019

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