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Article

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

Nature - 12 Aug 2004

Hernando Eva, Nahlé Zaher, Juan Gloria, Diaz-Rodriguez Elena, Alaminos Miguel, Hemann Michael, Michel Loren, Mittal Vivek, Gerald William, Benezra Robert, Lowe Scott W, Cordon-Cardo Carlos

Abstract excerpt

Advanced human cancers are invariably aneuploid, in that they harbour cells with abnormal chromosome numbers. However, the molecular defects underlying this trait, and whether they are a cause or a consequence of the malignant phenotype, are not clear. Mutations that disable the retinoblastoma (Rb) pathway are also common in human cancers. These mutations promote tumour development by deregulating the E2F family...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15306814
DOI: 10.1038/nature02820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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