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Article

MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2015

Hommers Leif, Raab Annette, Bohl Alexandra, Weber Heike, Scholz Claus-Jürgen, Erhardt Angelika, Binder Elisabeth, Arolt Volker, Gerlach Alexander, Gloster Andrew, Kalisch Raffael, Kircher Tilo, Lonsdorf Tina, Ströhle Andreas, Zwanzger Peter, Mattheisen Manuel, Cichon Sven, Lesch Klaus-Peter, Domschke Katharina, Reif Andreas, Lohse Martin J, Deckert Jürgen

Abstract excerpt

Regulator of G-protein Signaling 2 (RGS2) is a key regulator of G-protein-coupled signaling pathways involved in fear and anxiety. Data from rodent models and genetic analysis of anxiety-related traits and disorders in humans suggest down-regulation of RGS2 expression to be a risk factor for anxiety. Here we investigated, whether genetic variation in microRNAs mediating posttranscriptional down-regulation of RGS2...

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Identifiers

PMID: 25847876
DOI: 10.1002/ajmg.b.32312

Genes

RGS2
CNR1
IKBKE

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