Article
RGS2 ggenetic variation: association analysis with panic disorder and dimensional as well as intermediate phenotypes of anxiety.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2015
Hohoff Christa, Weber Heike, Richter Jan, Domschke Katharina, Zwanzger Peter M, Ohrmann Patricia, Bauer Jochen, Suslow Thomas, Kugel Harald, Baumann Christian, Klauke Benedikt, Jacob Christian P, Fritze Jürgen, Bandelow Borwin, Gloster Andrew T, Gerlach Alexander L, Kircher Tilo, Lang Thomas, Alpers Georg W, Ströhle Andreas, Fehm Lydia, Wittchen Hans-Ulrich, Arolt Volker, Pauli Paul, Hamm Alfons, Reif Andreas, Deckert Jürgen
Abstract excerpt
Accumulating evidence from mouse models points to the G protein-coupled receptor RGS2 (regulator of G-protein signaling 2) as a promising candidate gene for anxiety in humans. Recently, RGS2 polymorphisms were found to be associated with various anxiety disorders, e.g., rs4606 with panic disorder (PD), but other findings have been negative or inconsistent concerning the respective risk allele. To further examine...
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