Article
Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease.
Pharmacological reviews - 1 Jul 2018
Squires Katherine E, Montañez-Miranda Carolina, Pandya Rushika R, Torres Matthew P, Hepler John R
Abstract excerpt
Regulators of G protein signaling (RGS) proteins modulate the physiologic actions of many neurotransmitters, hormones, and other signaling molecules. Human RGS proteins comprise a family of 20 canonical proteins that bind directly to G protein-coupled receptors/G protein complexes to limit the lifetime of their signaling events, which regulate all aspects of cell and organ physiology. Genetic variations account...
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