Article
Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry.
Nature human behaviour - 1 Aug 2026
Skelton Megan, Mitchell Brittany L, Assary Elham, Li Danyang, Morneau-Vaillancourt Genevieve, Murphy Alan E, Ter Kuile Abigail R, Wang Rujia, Adams Mark J, Byrne Enda M, Corfield Elizabeth C, Grimes Poppy Z, Hannigan Laurie J, Hu Jihua, Kõiv Kadri, Kwong Alex S F, Papiol Sergi, Pettersen Johanne H, Pistis Giorgio, Castelao Enrique, Strom Nora I, van der Most Peter J, Andreassen Ole A, Erhardt-Lehmann Angelika, Havdahl Alexandra, Skene Nathan, Verhulst Brad, Weber Heike, Armour Chérie, Ask Helga, Copeland William E, Dannlowski Udo, Deckert Jürgen, Domschke Katharina, Hickie Ian B, Lehto Kelli, Lonsdorf Tina B, Lueken Ulrike, Lupton Michelle K, Medland Sarah E, McIntosh Andrew M, Oldehinkel Albertine J, Preisig Martin, Reif Andreas, Snieder Harold, Walters James T R, Wray Naomi R, Hartman Catharina A, Martin Nicholas G, Hettema John M, Breen Gerome, Coleman Jonathan R I, Eley Thalia C
Abstract excerpt
Anxiety is heritable and exists on a continuum, with symptoms ranging from adaptive threat response to clinical disorder. Here we performed a genome-wide association meta-analysis of generalized anxiety symptom severity in 693,869 individuals of European ancestry from 14 cohorts. We identified 80 independent genome-wide significant variants within 74 loci, 39 of which were newly associated with anxiety. SNP-based...
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