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Article

A novel autophagy-independent, oncosuppressive function of BECN1: Degradation of MCL1.

Autophagy - 1 Jan 2015

Elgendy Mohamed, Minucci Saverio

Abstract excerpt

The discovery that heterozygous disruption of Becn1 in mice leads to spontaneous tumor development was the first direct link arguing for a predominantly tumor-suppressor function of autophagy. However, the mechanisms by which BECN1 restrains tumorigenesis and whether autophagy-independent functions of BECN1 contribute to its tumor-restraining potential remained unexplored. We recently described a novel function...

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Source

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Identifiers

PMID: 25837021
DOI: 10.1080/15548627.2015.1029836
PMCID: PMC4502650

Genes

BECN1
MCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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