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Article

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003

Yue Zhenyu, Jin Shengkan, Yang Chingwen, Levine Arnold J, Heintz Nathaniel

Abstract excerpt

The biochemical properties of beclin 1 suggest a role in two fundamentally important cell biological pathways: autophagy and apoptosis. We show here that beclin 1-/- mutant mice die early in embryogenesis and beclin 1+/- mutant mice suffer from a high incidence of spontaneous tumors. These tumors...

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Identifiers

PMID: 14657337
DOI: 10.1073/pnas.2436255100
PMCID: PMC299911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14657337-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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