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Article

Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity.

Autophagy - 1 Jan 2014

Cicchini Michelle, Chakrabarti Rumela, Kongara Sameera, Price Sandy, Nahar Ritu, Lozy Fred, Zhong Hua, Vazquez Alexei, Kang Yibin, Karantza Vassiliki

Abstract excerpt

Earlier studies reported allelic deletion of the essential autophagy regulator BECN1 in breast cancers implicating BECN1 loss, and likely defective autophagy, in tumorigenesis. Recent studies have questioned the tumor suppressive role of autophagy, as autophagy-related gene (Atg) defects generally suppress tumorigenesis in well-characterized mouse tumor models. We now report that, while it delays or does not...

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Source

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Identifiers

PMID: 25483966
DOI: 10.4161/auto.34398
PMCID: PMC4502817

Genes

BECN1
WNT1
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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