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Article

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.

Genes & development - 1 Jan 2014

Kelly Gemma L, Grabow Stephanie, Glaser Stefan P, Fitzsimmons Leah, Aubrey Brandon J, Okamoto Toru, Valente Liz J, Robati Mikara, Tai Lin, Fairlie W Douglas, Lee Erinna F, Lindstrom Mikael S, Wiman Klas G, Huang David C S, Bouillet Philippe, Rowe Martin, Rickinson Alan B, Herold Marco J, Strasser Andreas

Abstract excerpt

The transcriptional regulator c-MYC is abnormally overexpressed in many human cancers. Evasion from apoptosis is critical for cancer development, particularly c-MYC-driven cancers. We explored which anti-apoptotic BCL-2 family member (expressed under endogenous regulation) is essential to sustain c-MYC-driven lymphoma growth to reveal which should be targeted for cancer therapy. Remarkably, inducible Cre-mediated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Survival

Share to Gene Expression Regulation, Neoplastic

Share to Lymphoma

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Proto-Oncogene Proteins c-myc

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 24395247
DOI: 10.1101/gad.232009.113
PMCID: PMC3894413

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.PMID 24395247Read ↗

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Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.Semantic proximity Read ↗

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