Article
Sequence analysis of NAT2 gene in Brazilians: identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure.
Mutation research - 5 Jan 2010
Teixeira Raquel L F, Silva Floriano P, Silveira Aline R, Cabello Pedro H, Mendonça-Lima Leila, Rabahi Marcelo F, Kritski Afrânio L, Mello Fernanda C Q, Suffys Philip N, de Miranda Antonio B, Santos Adalberto R
Abstract excerpt
N-Acetyltransferase 2 (NAT2) metabolizes a variety of xenobiotics that includes many drugs, chemicals and carcinogens. This enzyme is genetically variable in human populations and polymorphisms in the NAT2 gene have been associated with drug toxicity and efficacy as well as cancer susceptibility. Here, we have focused on the identification of NAT2 variants in Brazilian individuals from two different regions, Rio...
Topics
- Acetylation
- Arylamine N-Acetyltransferase
- Brazil
- Case-Control Studies
- Haplotypes
- Humans
- Models, Molecular
- Molecular Structure
- Polymorphism, Single Nucleotide