Article
Polymorphic GT dinucleotide repeat in the PIK3CA gene and risk of colorectal cancer.
Cancer biomarkers : section A of Disease markers - 1 Jan 2015
Parsafar Soha, Hematti Simin, Ghorbani Fateme, Safari Forousan, Tavassoli Manoochehr
Abstract excerpt
BACKGROUND: Activated PI3K generate PIP3 to trigger different signaling pathways which regulate a number of cellular functions including cell survival, apoptosis, proliferation and motility. Mutations in many cancers were discovered in the gene encoding the PI3K catalytic subunit, PIK3CA. OBJECTIVE: To date, there has been no report on the association between polymorphism of PIK3CA gene microsatellites and risk...
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