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Article

The PTPN13 Y2081D (T>G) (rs989902) polymorphism is associated with an increased risk of sporadic colorectal cancer.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Jul 2017

Laczmanska I, Karpinski P, Gil J, Laczmanski L, Makowska I, Bebenek M, Ramsey D, Sasiadek M M

Abstract excerpt

AIM: Colorectal cancer (CRC) is one of the most common cancers worldwide and, although the majority of cases are sporadic, its development and progression depends on a range of factors: environmental, genetic and epigenetic. A variety of genetic pathways have been described as being crucial in CRC, including protein tyrosine phosphatases (PTPs). PTPN13 (also called FAP-1) is a non-receptor PTP and interacts with...

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Identifiers

PMID: 28504867
DOI: 10.1111/codi.13727

Genes

PTPN13
FAP

Variants

rs989902

Provenance

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