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Article

Genetic analysis of key players in PI3K signaling cascade of colorectal carcinoma.

Scientific reports - 27 Feb 2026

Pervaiz Hira, Masood Nosheen, Malik Parvez Azam, Khan Jahangir Sarwar, Khan Mumtaz Ahmad, Malik Hassaan

Abstract excerpt

Triggering PI3K signaling cascade is most common in human cancers. This study aimed to screen the association of seven SNPs and two hotspot mutations, clinical outcome and therapeutic potential with susceptibility to colorectal carcinoma (CRC). In this case-control study of 495 CRC and 495 controls, seven SNPs were genotyped by ARMS-PCR. The mutant allele frequencies were significantly higher for five SNPs, E542K...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41760869
DOI: 10.1038/s41598-026-42006-z
PMCID: PMC13048996

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