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Article

PHLPP2 gene L1016S (rs61733127) and PIK3R1 gene Met326Ile (rs3730089) polymorphisms are associated with the risk of colon and breast cancers.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2021

Daneshvar Gelareh, Boostani Saghar, Moghanibashi Mehdi, Mohamadynejad Parisa

Abstract excerpt

The PIK3R1 and PHLPP2 genes encode the p85 alpha subunit of PI3K and a phosphatase for AKT, respectively, which play a direct role in regulating the PI3K-AKT pathway that promotes cell survival, growth, and differentiation. While most attention is focused on the factors that positively affect this pathway, negative regulation is equally important. The aim of this study was to investigate the association of SNPs...

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Identifiers

PMID: 34193013
DOI: 10.1080/15257770.2021.1944636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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