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Article

Genes from a translational analysis support a multifactorial nature of white matter hyperintensities.

Stroke - 1 Feb 2015

Lopez Lorna M, Hill W David, Harris Sarah E, Valdes Hernandez Maria, Munoz Maniega Susana, Bastin Mark E, Bailey Emma, Smith Colin, McBride Martin, McClure John, Graham Delyth, Dominiczak Anna, Yang Qiong, Fornage Myriam, Ikram M Arfan, Debette Stephanie, Launer Lenore, Bis Joshua C, Schmidt Reinhold, Seshadri Sudha, Porteous David J, Starr John, Deary Ian J, Wardlaw Joanna M

Abstract excerpt

BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) of presumed vascular origin increase the risk of stroke and dementia. Despite strong WMH heritability, few gene associations have been identified. Relevant experimental models may be informative. METHODS: We tested the associations between genes that were differentially expressed in brains of young spontaneously hypertensive stroke-prone rats and human...

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Source

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Identifiers

PMID: 25586835
DOI: 10.1161/STROKEAHA.114.007649
PMCID: PMC4306534

Genes

AFP
ALB
FARP1
GNAI1
MRPL18
PMF1
TRIM47
TRIM65
XPNPEP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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