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Cerebral small vessel disease genomics and its implications across the lifespan

8 Dec 2020

Abstract excerpt

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in...

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Share to Cerebrovascular and genetic disorders
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PMID: 33293549
DOI: 10.1038/s41467-020-19111-2

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