Article

Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography

2023-12-17

Abstract excerpt

Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system x c − , is one of the >200 cytoprotective proteins controlled by NRF2, which can be non-invasively imaged by ( S )-4-(3- 18 F-fluoropropyl)-ʟ-glutamate ([ 18 F]FSPG) positron emission tomography (PET). Through g...

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Literature Corpus work: 9ee391cc-dfe9-5d9c-8bef-0394e34b250c
DOI: 10.1101/2023.12.16.572007

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